The reference site for Glimepiride

Glimepiride (original trade name Amaryl) is an orally available medium-to-long-acting sulfonylurea antidiabetic drug. It is sometimes classified as either the first third-generation sulfonylurea, or as second-generation.


Glimepiride is an oral diabetes medicine that helps control blood sugar levels. This medication helps your body respond better to insulin produced by your pancreas.

Glimepiride is used together with diet and exercise to treat type 2 (non-insulin dependent) diabetes. When required, other diabetes medicines are sometimes used in combination with glimepiride.


Brand Name(s): Amaryl
CAS nº: 93479-97-1
(glye’ me pye ride)


Product Info

The sections below will provide you with more specific information and guidelines related to glimepiride and its correct use. Please read them carefully.

FDA Information

Glimepiride was approved by the FDA in December 1995.

In July 2005, Ranbaxy Pharmaceuticals Inc. received tentative approval from the U.S. Food and Drug Administration to manufacture and market glimepiride tablets in 3 milligram and 6 milligram strengths.

The brand version of glimepiride, Amaryl®, has annual sales of $336.6 million. Amaryl® is a registered trademark of Aventis Pharmaceuticals Inc., based in Bridgewater, N.J.

Please visit the official site of the FDA for further information.

Why is this medication prescribed?

Glimepiride is an oral blood sugar-lowering drug in a class of medicines called sulfonylureas, used for controlling diabetes.

This medication is related to other sulfonylureas including glyburide (Micronase® and Diabeta®), glipizide (Glucotrol®), tolbutamide (Orinase®) and tolazamide (Tolinase®).

Glimepiride is used in type II diabetes, the most common type of diabetes that is found in 90% of patients with diabetes. In type II diabetes, insulin usually is not necessary to control the blood sugar. Instead, diet and oral medications often are sufficient. Intolerance to sugar that results in elevated blood sugar is caused by reduced insulin secretion by the pancreas and resistance to insulin’s effects by the body’s cells. Glimepiride works by lowering the sugar level in the blood by stimulating insulin to be secreted from the pancreas into the blood. Insulin causes sugar to leave the blood and enter cells throughout the body.

Other uses for this medicine

Glimepiride is sometimes prescribed for other uses. Therefore, it is advised that you consult your doctor or pharmacist for further information before taking this medication.

Dosage and using this medicine

Glimepiride comes as a tablet to be taken orally.

It is usually taken once a day. The tablet should be taken with breakfast or the first big meal of the day.

Take glimepiride exactly as directed by your doctor. Do not take more or less of it or take it more often than prescribed by your doctor.

Take care not to let your blood sugar get too low, causing hypoglycemia. You may have hypoglycemia if you skip a meal, exercise too long, drink alcohol, or are under stress.

It is important that you know the signs of low blood sugar (hypoglycemia) and how to recognize them. Always keep a source of sugar available in case you have symptoms of low blood sugar. Sugar sources include orange juice, glucose gel, candy, or milk. Severe hypoglycemia may cause loss of consciousness, seizures, or death. If you have severe hypoglycemia and cannot eat or drink, use an injection of glucagon. Your doctor can give you a prescription for a glucagon emergency injection kit and tell you how to give the injection.

Additionally, glimepiride is only part of a complete program of treatment that also includes diet, exercise, and weight control. Follow your diet, medication, and exercise routines very closely.

Continue to take glimepiride even if you feel well. and do not stop taking glimepiride without first talking to your doctor.

What special precautions should I follow?


Tell your doctor and pharmacist if you are allergic to glimepiride or any other drugs.

Inform your doctor and pharmacist what prescription and non-prescription medications you are taking, especially antibiotics, anticoagulants (‘blood thinners’) such as warfarin (Coumadin®), dexamethasone (Decadron®), diuretics (‘water pills’), estrogens, isoniazid (INH), MAO inhibitors [phenelzine (Nardil®) and tranylcypromine (Parnate®)], medications for high blood pressure or heart disease, niacin, oral contraceptives, phenytoin (Dilantin®), prednisone, probenecid (Benemid®), and vitamins.

Moreover, you should tell your doctor if you have or have ever had kidney disease or ketoacidosis.

If you are pregnant, plan to become pregnant, or are breast-feeding while taking glimepiride, call your doctor immediately.

Also, if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking glimepiride.

What should I do if I forget a dose?

Take the missed dose of glimepiride as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule.

It is strongly advised not to take a double dose to make up for a missed one.

What side effects can this medication cause?

Possible side effects from using glimepiride may include:

dizziness or weakness
headache, blurred vision
mild nausea, vomiting, or stomach pain
increased skin sensitivity to sunlight
dark urine

Tell your doctor if any of these symptoms are severe or do not go away:

signs of congestive heart failure (swelling or rapid weight gain, shortness of breath, chest pain)
muscle cramps
skin rash
easy bruising or bleeding
unusual weakness
low fever
loss of appetite
dark urine

If you experience any of the following symptoms, call your doctor immediately:

allergic reaction (hives, difficulty breathing, swelling of your face, lips, tongue, or throat)

Call your doctor immediately if you have any of the following symptoms of hyperglycemia (high blood sugar):

extreme thirst
frequent urination
extreme hunger
blurred vision

Eat or drink a food or beverage with sugar in it, such as hard candy or fruit juice, and call your doctor immediately if you have any of the symptoms of hypoglycemia (low blood sugar):

dizziness or lightheadedness
nervousness or irritability
sudden changes in behavior or mood
numbness or tingling around the mouth
pale skin
sudden hunger
clumsy or jerky movements

Glimepiride may cause other side effects. Call your doctor if you have any unusual problems that are not mentioned above while taking this medication.

What storage conditions are needed for this medicine?

Always keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom).

It is recommended that you throw away any medication that is outdated or no longer needed. Should you have any questions regarding this, please talk to your pharmacist about the proper disposal of your medication.

In case of an emergency/overdose

In the case of a suspected overdose, call your local poison control center on 1-800-222-1222. However, if the victim has collapsed or is not breathing, then please call the local emergency services on 911.

Symptoms of a glimepiride overdose may include:

cold sweats
loss of consciousness and coma

Product Images


Below you will find images and specific information on the principal types of glimepiride that exist, including their respective brand name(s), strength, inscription codes and manufacturers.

The information below includes general information and guidelines for patients taking this medication and should never be used to substitute professional medical advice that can be provided by a qualified physician or family doctor.

Strength(s): 2 MG
Imprint: RDY | 3 21
Manufacturer: DR. REDDY’S LABS.

Strength(s): 2 MG
Imprint: RB | 49
Manufacturer: RANBAXY

Strength(s): 2 MG
Imprint: AMARYL
Manufacturer: AVENTIS PHARM.

Strength(s): 2 MG
Imprint: 93 | 7255

Strength(s): 4 MG
Imprint: AMARYL
Manufacturer: AVENTIS PHARM.

Strength(s): 4 MG
Imprint: RDY | 3 22
Manufacturer: DR. REDDY’S LABS.

Strength(s): 4 MG
Imprint: RB | 50
Manufacturer: RANBAXY

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